Our Pipeline

The SparX Selected IO & Nab2-ADC Pipeline

Candidate	Target	Research	Lead Optimization	Pre-Clinical Development	IND-Enabling	Phase I	Phase II
SPX-303	LILRB2xPDL1	Mayo Clinic Rochester, Arizona & Florida					First-in-Class
SPX-303	LILRB2xPDL1+T-DXd	MRCT, Simon’s 2-Stage (Futility assessment in 3 indications)					First-in-Class
SPX-308	VEGF X PD-L1 ^biparat						Differentiated
SPX-602	VEGFxPDL1-DXd						First-in-Class
SPX-306	Oral IL23xTL1A						First-in-Class
CAR-iNKT	CLDN 18.2				Arovella Collaboration		First-in-Class
SPX-701	NGF/TNFα				MNC Collaboration		First-in-Class
SPT-101	LILRB2-ADC				MNC Collaboration		First-in-Class

SPX-303* Target: αLILRB2 X PD-L1

Research | Lead Optimization | Pre-Clinical Development | IND-Enabling | Phase 1

SPX-104 Target: αLILRB2 + PD-1

Research | Lead Optimization | Pre-Clinical Development | IND-Enabling

SPX-308* Target: sdVEGF X sdPD-L1

Research | Lead Optimization | Pre-Clinical Development

SPX-101¹ Target: CLDN 18.2

Research | Lead Optimization | Pre-Clinical Development | IND-Enabling | Phase 1

SPX-102* Target: CLDN 18.2-CDx

Research | Lead Optimization | Pre-Clinical Development | IND-Enabling | Phase 1

SPX-306^+,1 Target: Undisclosed

Research | Lead Optimization | Pre-Clinical Development | IND-Enabling

SPX-603* Target: VEGFxPD-L1-ADC

Research | Lead Optimization | Pre-Clinical Development

Candidate: SPX-101 | Target: CLDN 18.2

Discovery | Pharmacology | GLD/GLP | IND Enabling | IND | Phase 1

Candidate: SPX-102 | Target: CLDN 18.2

Discovery | Pharmacology | GLD/GLP | IND Enabling | IND | Phase 1

Candidate: SPX-104 | Target: LILRB2

Discovery | Pharmacology | GLD/GLP

Candidate: SPX-301 | Target: CLDN X Chkpt

Discovery | Pharmacology

Candidate: SPX-302 | Target: Bispecific

Discovery | Pharmacology | GLD/GLP | IND Enabling

Candidate: SPX-303 | Target: LILRB2 X Chkpt

Discovery | Pharmacology | GLD/GLP

Candidate: SPX-304 | Target: Bispecific

Discovery | Pharmacology

Candidate: SPX-306 | Target: Bispecific

Discovery | Pharmacology

Get in Touch with SparX