The SparX Group is an emerging biotech powerhouse best known for its multi-specific antibody and antibody drug conjugate (ADC) discovery platforms. With a mission to “Recover Human Immunity by Empowered Antibody Therapies”, SparX has leveraged artificial intelligence to drive its proprietary target mining engine, allowing identification of cellular targets which can best be leveraged for optimal and synergistic biological activity. This sophisticated target discovery platform is combined with an integrated multi-component SAILING™ antibody optimization system and four cutting-edge ADC technologies to markedly improve the success rate of empowered antibody drug development. In addition to the integrated antibody discovery platform, SparX has built in-house GMP facilities of significant capacity in both Chicago and China to produce clinical and commercial drug products, allowing its evolution into an integrated and independent biopharmaceutical company.
SparX is seeking a highly motivated and enthusiastic Associate Scientist in protein expression, purification and characterization. The role will involve cell culture, plasmid preparation, protein expression and purification using a variety of cell culture systems, protein characterization, and evaluation. The ideal candidate will have 2-5 years of laboratory experience with a B.A./B.S. degree, or 0-2 years of experience with MS degree in biochemistry, molecular biology, or related discipline. Research experience involving protein expression and purification is a must, preferable with antibody expression and purification
Principal Duties and Responsibilities:
- Assisting senior scientists in the various stages of experiments
- Performing basic laboratory procedures, majorly in protein expression and purification
- Following SOPs and experimental protocols
- Keeping detailed record of all technical manipulations and results
- Conducting and troubleshooting experiments in the field of protein expression, purification, and characterization
- Contributing to laboratory organization and maintenance
- BS/MS with experience in basic molecular biology (plasmid construction and preparation, mutagenesis with genetic engineering)
- Experience in protein expression, purification and characterization using classic column chromatography (affinity, IEX, gel filtration)
- Characterize purified proteins using different analytical techniques (SDS-PAGE, Western blot, etc.)
- Collaborative and proactive attitude
- Experience with protein expression in mammalian expression system
- Experience with AKTA system
About SparX Group
SparX Biopharmaceutical Corp. is a research-based development-stage biopharmaceutical company, dedicated to the mission of “strengthening human immunity using robust antibody therapies” through the discovery and development of innovative immuno-oncology agents. Equipped with big data analytical techniques, such as machine learning algorithms, SparX extracts potential interactions from large volumes of complex multi-dimensional public information. Mechanistic pharmacological analyses coupled with in vitro and in vivo evaluations using the syngeneic, transgenic and humanized mouse models, enables SparX’s focus on developing novel or best-in-class therapeutics demonstrating substantial advantages over existing therapies.
Target discovery and validation has historically been the bottleneck in drug development. SparX combines its sophisticated target discovery platform with an integrated multi-component SAILING™ antibody optimization system and a cutting-edge bi-ADC technology to markedly improve the success rate of empowered antibody drug development. In addition to the integrated antibody discovery platform, SparX has built in-house cGMP facilities of significant capacity to produce clinical and commercial drug products, facilitating its evolution into an integrated and independent biopharmaceutical company.
Sparx is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates. Sparx is committed to providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, national origin, age, disability, marital status, sexual orientation, genetic information, uniform service member or veteran status, or any other characteristic protected by federal, state or local law. Further, Sparx complies with all applicable national, state, and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Sparx is an e-verify employer.