Title: Senior Scientist Downstream Bioprocess Development
Location: West Suburb of Chicago
Primary responsibility:
We are seeking a highly motivated and enthusiastic Senior Scientist in Downstream Process of Biologics Development located in Mount Prospect, IL. The successful candidate will be working on purification processes to produce recombinant proteins for therapeutics application. The candidate will be responsible for the development and implementation of downstream processing methodologies and analytical procedures that are amendable to cGMP manufacturing. You will be also supporting other groups including Cell Line Development and Upstream Process Development. The ideal candidate will have 2 years of industry experience with a Ph.D. degree, or 5 years of industry experience with an MS degree in Chemical/Biochemical Engineering, Biotechnology, Cell Biology, Biochemistry, or related disciplines.
Principal Duties and Responsibilities:
- Develop robust, scalable, and cost-effective purification processes for large scale protein production.
- Perform experiments using AKTA series chromatography skids, TFF systems, and industry standard of harvest methods.
- Lead efforts to evaluate different resins, filters, and analytical methods pertinent to purification development activities.
- Develop, optimize and scale-up purification methods to meet cGMP and Regulatory Compliance using Design of Experiment (DoE) methods.
- Design and execute protein purification experiments, and data interpretation from benchtop to pilot scale.
- Provide technical leadership to downstream process development.
- Authoring associated technical reports for regulatory filings and documents all fermentation activities according to cGMP standards.
Required Qualifications:
- A Ph.D. degree in Chemical/Biochemical Engineering, or Biotechnology, Biochemistry, or related disciplines with 2 years of industry experience or an MS degree in these areas with 5 years of industry experience.
- In depth understanding and strong hands-on experience in antibody purification process.
- Good problem-solving skills. Capable of finding the root cause of problems and solve them effectively.
- Ability to work within ISO 5/6/7/8 clean room environments.
- Experience in cGMP, CMC activities is a plus.
- Collaborative and proactive attitude.
Desired Qualifications:
- Highly experienced with downstream process development of bio-products, including essential techniques for mammalian cell culture based viral and protein purification techniques e.g. Ă„KTA series chromatography skids, Depth filtration, Tangential flow filtration or UF/DF, respectively.
- Strong grasp of chromatography principles and modalities.
- Strong understanding of the principles of Quality by Design and ability to apply DoE to downstream development.
- Knowledge of basic analytical tools such as spectrophotometry, ELISA, HPLC, and SDS-PAGE.
- Demonstrate an ability to multi-task and manage multiple projects independently. Maintain a safe work environment for self and staff.
- Knowledgeable with cGMP manufacturing under cGMP/cGLP compliance.
- Excellent interpersonal and communication skills
- Experience mentoring junior staff regarding laboratory procedures and scientific projects
About SparX Group
SparX Biopharmaceutical Corp. is a research-based development-stage biopharmaceutical company, dedicated to the mission of “strengthening human immunity using robust antibody therapies” through the discovery and development of innovative immuno-oncology agents. Equipped with big data analytical techniques, such as machine learning algorithms, SparX extracts potential interactions from large volumes of complex multi-dimensional public information. Mechanistic pharmacological analyses coupled with in vitro and in vivo evaluations using the syngeneic, transgenic and humanized mouse models, enables SparX’s focus on developing novel or best-in-class therapeutics demonstrating substantial advantages over existing therapies.
Target discovery and validation has historically been the bottleneck in drug development. SparX combines its sophisticated target discovery platform with an integrated multi-component SAILING™ antibody optimization system and a cutting-edge bi-ADC technology to markedly improve the success rate of empowered antibody drug development. In addition to the integrated antibody discovery platform, SparX has built in-house cGMP facilities of significant capacity to produce clinical and commercial drug products, facilitating its evolution into an integrated and independent biopharmaceutical company.
EEOC Statement:
Sparx is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates. Sparx is committed to providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, national origin, age, disability, marital status, sexual orientation, genetic information, uniform service member or veteran status, or any other characteristic protected by federal, state or local law. Further, Sparx complies with all applicable national, state, and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Sparx is an e-verify employer.
