Technology: Key features of the Sparx Bifunctional ADC technology

  • Proprietary cutting-edge multi-specific antibody strategies to ensure exquisite specificity and optimal internalization
  • Homogenous glycosylation profile enabled by proprietary NECORTM technology
  • Flexible site-specific conjugation schema powered by NECOR TM and site-specific mutations
  • Homogenous ADCs with customized DARs (drug-to-antibody ratio) of 2, 4, 6, or 8
  • Protease or caspase-dependent peptide linkers to increase tumor accumulation and bystander effect
  • Consistency in product  from pilot to  manufacturing scale

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