{"id":3238,"date":"2022-12-11T03:59:45","date_gmt":"2022-12-11T03:59:45","guid":{"rendered":"\/?page_id=3238"},"modified":"2026-01-20T09:31:14","modified_gmt":"2026-01-20T09:31:14","slug":"our-pipeline","status":"publish","type":"page","link":"\/?page_id=3238","title":{"rendered":"Our Pipeline"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"3238\" class=\"elementor elementor-3238\">\n\t\t\t\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-938f035 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"938f035\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-79e80e9\" data-id=\"79e80e9\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-d09a034 elementor-widget elementor-widget-heading\" data-id=\"d09a034\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">The SparX Selected IO & Nab2-ADC Pipeline<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-ebd3b4e elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"ebd3b4e\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-07bd565\" data-id=\"07bd565\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-25a6f03 elementor-widget elementor-widget-html\" data-id=\"25a6f03\" data-element_type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t    <style>\n        .progress-bar {\n            width: 100%;\n            height: 20px;\n            background-color: #ddd;\n            overflow: hidden;\n        }\n        \n        .progress {\n            width: 0;\n            height: 100%;\n            background-color: #69BAEC;\n            animation: progressAnimation 2s ease-in-out forwards;\n        }\n    \n        .inter .progress {\n            background-color: #fafafa;\n        }\n    \n        .progress-container {\n        width: 100%;\n        height: 40px;\n        background: #fff;\n        margin: 0;\n        position: relative;\n    }\n    \n    .progress-fill {\n        height: 100%;\n        width: 50%; \/* \u521d\u59cb\u8fdb\u5ea6 *\/\n        background: linear-gradient(45deg, #69BAEC, #4d9bcb);\n        background-size: contain;\n        position: relative;\n        transition: width 0.6s ease;\n        clip-path: polygon(0 0, calc(100% - 20px) 0, 100% 50%, \n                         calc(100% - 20px) 100%, 0 100%); \/* \u7f51\u98757\u7684\u7bad\u5934\u53d8\u5f62 *\/\n                         display: flex;          \/* \u542f\u7528\u5f39\u6027\u5e03\u5c40 *\/\n                         justify-content: flex-start; \n        vertical-align: middle;\n    }\n\n    .progress-fill *{\n        margin: 0 5px 0 0;\n    }\n\n    .progress-fill b{\n        margin: 5px;\n    }\n\n    .progress-fill > :last-child {\n        margin-left: auto; \n        margin-right: 15px;  \n    }\n    \n    .inter .progress-fill {\n        background: linear-gradient(45deg, #ccc, #999); \n    }\n    .inter2 .progress-fill {\n    background: linear-gradient(45deg, #ddba62, #F6C242); \n    }\n\n    .content {\n        position: absolute;\n        display: flex;\n        align-items: center;\n        padding: 0 15px;\n        height: 100%;\n        color: white;\n    }\n    \n    .badge {\n        width: 30px;\n        height: 30px;\n        margin-right: 10px;\n    }\n    \n    \/* \u7f51\u98756\u7684\u4f2a\u5143\u7d20\u7bad\u5934\u589e\u5f3a *\/\n    .progress-fill::after {\n        content: '';\n        position: absolute;\n        right: -20px;\n        top: 0;\n        border-left: 20px solid #69BAEC;\n        border-top: 20px solid transparent;\n        border-bottom: 20px solid transparent;\n    }    \n        \n        @keyframes progressAnimation {\n            0% { width: 10%; }\n            100% { width: 100%; }\n        }\n        \n        table {\n            border-collapse: collapse;\n            width: 100%;\n            margin: 20px 0;\n            font-family: Arial, sans-serif;\n        }\n        \n        #pipeline-table th, #pipeline-table td {\n            border: 1px solid #ddd;\n            padding: 12px;\n            text-align: left;\n        }\n    \n        #pipeline-table td{\n            padding: 5px;\n            background-color: #fff;\n            vertical-align: middle\n        }\n    \n        #pipeline-table td:last-child{\n            text-align: right;\n        }\n    \n        #pipeline-table td:last-child{\n            text-align: right;\n        }\n        \n        #pipeline-table td:first-child{\n            font-weight: bold;\n        }\n    \n        #pipeline-table th {\n            background: #606060;\n            color: #fff;\n            font-size: 12px;\n        }\n        \n        tr:nth-child(even) {\n            background-color: #f9f9f9;\n        }\n        \n        .stage-header {\n            white-space: nowrap;\n        }\n    \n        \n        \n        @media screen and (max-width: 768px) {\n            table {\n                overflow-x: auto;\n                display: block;\n            }\n        }\n        <\/style>\n        <\/head>\n        <body>\n        \n<table id=\"pipeline-table\">\n    <thead>\n        <tr>\n            <th>Candidate<\/th>\n            <th width=\"20%\">Target<\/th>\n            <th class=\"stage-header\">Research<\/th>\n            <th class=\"stage-header\">Lead Optimization<\/th>\n            <th class=\"stage-header\">Pre-Clinical Development<\/th>\n            <th class=\"stage-header\">IND-Enabling<\/th>\n            <th class=\"stage-header\">Phase I<\/th>\n            <th class=\"stage-header\">Phase II<\/th>\n        <\/tr>\n    <\/thead>\n    <tbody>\n        <!-- SPX-303 -->\n        <tr>\n            <td rowspan=\"2\" style=\"background-color: yellow;\">SPX-303<\/td>\n            <td>LILRB2xPDL1<\/td>\n            <td colspan=\"5\" class=\"inter\">\n                <div class=\"progress-bar progress-container\">\n                    <div class=\"progress progress-fill\">\n                        <img decoding=\"async\" src=\"\/app\/uploads\/2025\/04\/us.webp\" alt=\"US\" \/>\n                         <img decoding=\"async\" height=\"40px\" style=\"background-color: yellow;\" src=\"http:\/\/sparxbio.com\/app\/uploads\/2025\/04\/image9-2.png\" alt=\"\"> <b style=\"font-size: 14px;color: yellow; line-height: 1em;\">Mayo Clinic <br\/><small>(Minnesota, Arizona & Florida)<\/small><\/b> <img decoding=\"async\" height=\"40px\" src=\"http:\/\/sparxbio.com\/app\/uploads\/2025\/04\/image8-2.png\" alt=\"\"><b style=\"font-size: 14px;color: yellow;\">HonorHealth<\/b>\n                        <img decoding=\"async\" loading=\"lazy\" src=\"\/app\/uploads\/2025\/04\/image5-2.png\" width=\"36\" height=\"auto\" \/>\n                    <\/div>\n                <\/div>\n            <\/td>\n            <td>First-in-Class<\/td>\n        <\/tr>\n\n        <!-- SPX-303 + T-DXd -->\n        <tr>\n            <td>LILRB2xPDL1+T-DXd<\/td>\n            <td colspan=\"4\" class=\"inter\">\n                <div class=\"progress-bar progress-container\" style=\"width: 110%;\">\n                    <div class=\"progress progress-fill\">\n                        <img decoding=\"async\" src=\"\/app\/uploads\/2025\/04\/cn.webp\" alt=\"CN\" \/>\n                        <b>MRCT & in combination with T-DXd<\/b>\n                        <img decoding=\"async\" loading=\"lazy\" src=\"\/app\/uploads\/2025\/04\/image5-2.png\" width=\"36\" height=\"auto\" \/>\n                    <\/div>\n                <\/div>\n            <\/td><td><\/td>\n            <td>First-in-Class<\/td>\n        <\/tr>\n\n        <!-- SPX-629 -->\n        <tr>\n            <td style=\"background-color: yellow;\">SPX-629<\/td>\n            <td>HER2 Dual-Payload ADC (TOP1i \u00d7 MMAE)<\/td>\n         \n            <td colspan=\"4\" class=\"inter\">\n                  <div class=\"progress-bar progress-container\">\n                    <div class=\"progress progress-fill\">\n                        <img decoding=\"async\" src=\"\/app\/uploads\/2025\/04\/us.webp\" alt=\"US\" \/> <img decoding=\"async\" src=\"\/app\/uploads\/2025\/04\/cn.webp\" alt=\"CN\" \/>\n                        <img decoding=\"async\" loading=\"lazy\" src=\"\/app\/uploads\/2025\/04\/image5-2.png\" width=\"36\" height=\"auto\" \/>\n                    <\/div>\n                <\/div>                 \n\n            <\/td><td><\/td>\n            <td>Best-in-Class<\/td>\n        <\/tr>\n\n        <!-- SPX-602 -->\n        <tr>\n            <td style=\"background-color: yellow;\">SPX-602<\/td>\n            <td>VEGFxPDL1-ADC (TOP1i \u00d7 MMAE)<\/td>\n            <td colspan=\"4\" class=\"inter\">\n                <div class=\"progress-bar progress-container\">\n                    <div class=\"progress progress-fill\">\n                        <img decoding=\"async\" src=\"\/app\/uploads\/2025\/04\/us.webp\" alt=\"US\" \/> <img decoding=\"async\" src=\"\/app\/uploads\/2025\/04\/cn.webp\" alt=\"CN\" \/>\n                        <img decoding=\"async\" loading=\"lazy\" src=\"\/app\/uploads\/2025\/04\/image5-2.png\" width=\"36\" height=\"auto\" \/>\n                    <\/div>\n                <\/div>\n            <\/td><td><\/td>\n            <td>First-in-Class<\/td>\n        <\/tr>\n\n        <!-- SPX-608 -->\n        <tr>\n            <td style=\"background-color: yellow;\">SPX-608<\/td>\n            <td>Immune-Targeting Dual Payload ADC<\/td>\n            <td colspan=\"4\" class=\"inter\">\n                <div class=\"progress-bar progress-container\">\n                    <div class=\"progress progress-fill\">\n                        <img decoding=\"async\" src=\"\/app\/uploads\/2025\/04\/us.webp\" alt=\"US\" \/> <img decoding=\"async\" src=\"\/app\/uploads\/2025\/04\/cn.webp\" alt=\"CN\" \/>\n                        <img decoding=\"async\" loading=\"lazy\" src=\"\/app\/uploads\/2025\/04\/image5-2.png\" width=\"36\" height=\"auto\" \/>\n                    <\/div>\n                <\/div>\n            <\/td><td>Open for Collaboration <\/td>\n            <td>First-in-Class<\/td>\n        <\/tr>\n\n        <!-- TAA-ADC Platform -->\n        <tr>\n            <td style=\"background-color: #9FCE62\">TAA-ADC<\/td>\n            <td>Nab\u00b2\u2122 Dual-Payload ADC Platform<\/td>\n            <td colspan=\"3\">\n                 <div class=\"progress-bar progress-container\" style=\"width: 85%;\">\n                    <div class=\"progress progress-fill\">\n                        <img decoding=\"async\" src=\"\/app\/uploads\/2025\/04\/us.webp\" alt=\"US\" \/> <img decoding=\"async\" src=\"\/app\/uploads\/2025\/04\/cn.webp\" alt=\"CN\" \/>\n                        <img decoding=\"async\" loading=\"lazy\" src=\"\/app\/uploads\/2025\/04\/image5-2.png\" width=\"36\" height=\"auto\" \/>\n                    <\/div>\n                <\/div>               \n            <\/td><td><\/td><td>Platform Collaboration<\/td>\n            <td>First-in-Class<\/td>\n        <\/tr>\n\n        <!-- SPX-306 -->\n        <tr>\n            <td style=\"background-color: #F6C242;\">SPX-306<\/td>\n            <td>Oral IL23xTL1A<\/td>\n            <td colspan=\"3\" class=\"inter2\">\n                <div class=\"progress-bar progress-container\" style=\"width: 110%;\">\n                    <div class=\"progress progress-fill\">\n                        <img decoding=\"async\" src=\"\/app\/uploads\/2025\/04\/us.webp\" alt=\"US\" \/> <img decoding=\"async\" src=\"\/app\/uploads\/2025\/04\/cn.webp\" alt=\"CN\" \/>\n                        <img decoding=\"async\" loading=\"lazy\" src=\"\/app\/uploads\/2025\/04\/image5-2.png\" width=\"36\" height=\"auto\" \/>\n                    <\/div>\n                <\/div>\n            <\/td><td><\/td><td>NewCo Collaboration<\/td>\n            <td>First-in-Class<\/td>\n        <\/tr>\n\n        <!-- ALA-105 -->\n        <tr>\n            <td style=\"background-color: #387383\">ALA-105<\/td>\n            <td>CLDN 18.2-iNKT<\/td>\n            <td colspan=\"3\">\n                <div class=\"progress-bar progress-container\" style=\"width: 120%;\">\n                    <div class=\"progress progress-fill\">\n                        <img decoding=\"async\" src=\"\/app\/uploads\/2025\/04\/au.webp\" alt=\"US\" \/>\n                        <img decoding=\"async\" loading=\"lazy\" src=\"\/app\/uploads\/2025\/04\/image5-2.png\" width=\"36\" height=\"auto\" \/>\n                    <\/div>\n                <\/div>\n            <\/td><td><\/td><td>Arovella Collaboration<\/td>\n            <td>First-in-Class<\/td>\n        <\/tr>\n\n        <!-- SPX-701 -->\n        <tr>\n            <td style=\"background-color: #387383\">SPX-701<\/td>\n            <td>Bispecific Antibody<\/td>\n            <td colspan=\"3\">\n                <div class=\"progress-bar progress-container\" style=\"width: 120%;\">\n                    <div class=\"progress progress-fill\">\n                        <img decoding=\"async\" src=\"\/app\/uploads\/2025\/04\/cn.webp\" alt=\"US\" \/>\n                        <img decoding=\"async\" loading=\"lazy\" src=\"\/app\/uploads\/2025\/04\/image5-2.png\" width=\"36\" height=\"auto\" \/>\n                    <\/div>\n                <\/div>\n            <\/td><td><\/td><td>MNC Collaboration<\/td>\n            <td>First-in-Class<\/td>\n        <\/tr>\n\n        <!-- SPX-308 -->\n        <tr>\n            <td style=\"background-color: #7F7F7F\">SPX-308<\/td>\n            <td>VEGF x PD-L1 biparatopic<\/td>\n            <td colspan=\"3\" class=\"inter\">\n                <div class=\"progress-bar progress-container\" style=\"width: 120%;\">\n                    <div class=\"progress progress-fill\">\n                        <img decoding=\"async\" src=\"\/app\/uploads\/2025\/04\/us.webp\" alt=\"US\" \/>\n                        <img decoding=\"async\" loading=\"lazy\" src=\"\/app\/uploads\/2025\/04\/image5-2.png\" width=\"36\" height=\"auto\" \/>\n                    <\/div>\n                <\/div>\n            <\/td><td><\/td><td>Open for Collaboration<\/td>\n            <td>Best-in-Class<\/td>\n        <\/tr>\n    <\/tbody>\n<\/table>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-93f10d8 elementor-hidden-desktop elementor-hidden-tablet elementor-hidden-mobile elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"93f10d8\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-a4d9ce4\" data-id=\"a4d9ce4\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-26eb45a elementor-widget elementor-widget-progress\" data-id=\"26eb45a\" data-element_type=\"widget\" data-widget_type=\"progress.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t<span class=\"elementor-title\"><b style=\"font-size:20px\">SPX-303*<\/b> Target: \u03b1LILRB2 X PD-L1<\/span>\n\t\t\n\t\t<div class=\"elementor-progress-wrapper\" role=\"progressbar\" aria-valuemin=\"0\" aria-valuemax=\"100\" aria-valuenow=\"65\" aria-valuetext=\"Research | Lead Optimization | Pre-Clinical Development | IND-Enabling | Phase 1\">\n\t\t\t<div class=\"elementor-progress-bar\" data-max=\"65\">\n\t\t\t\t<span class=\"elementor-progress-text\">Research | Lead Optimization | Pre-Clinical Development | IND-Enabling | Phase 1<\/span>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ac0d543 elementor-widget elementor-widget-progress\" data-id=\"ac0d543\" data-element_type=\"widget\" data-widget_type=\"progress.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t<span class=\"elementor-title\"><b style=\"font-size:20px\">SPX-104<\/b> Target: \u03b1LILRB2 + PD-1<\/span>\n\t\t\n\t\t<div class=\"elementor-progress-wrapper\" role=\"progressbar\" aria-valuemin=\"0\" aria-valuemax=\"100\" aria-valuenow=\"55\" aria-valuetext=\"Research | Lead Optimization | Pre-Clinical Development | IND-Enabling\">\n\t\t\t<div class=\"elementor-progress-bar\" data-max=\"55\">\n\t\t\t\t<span class=\"elementor-progress-text\">Research | Lead Optimization | Pre-Clinical Development | IND-Enabling<\/span>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f88bc50 elementor-widget elementor-widget-progress\" data-id=\"f88bc50\" data-element_type=\"widget\" data-widget_type=\"progress.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t<span class=\"elementor-title\"><b style=\"font-size:20px\">SPX-308*<\/b> Target: sdVEGF X sdPD-L1<\/span>\n\t\t\n\t\t<div class=\"elementor-progress-wrapper\" role=\"progressbar\" aria-valuemin=\"0\" aria-valuemax=\"100\" aria-valuenow=\"40\" aria-valuetext=\"Research | Lead Optimization | Pre-Clinical Development\">\n\t\t\t<div class=\"elementor-progress-bar\" data-max=\"40\">\n\t\t\t\t<span class=\"elementor-progress-text\">Research | Lead Optimization | Pre-Clinical Development<\/span>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-709aa82 elementor-widget elementor-widget-progress\" data-id=\"709aa82\" data-element_type=\"widget\" data-widget_type=\"progress.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t<span class=\"elementor-title\"><b style=\"font-size:20px\">SPX-101<sup>1<\/sup><\/b> Target: CLDN 18.2<\/span>\n\t\t\n\t\t<div class=\"elementor-progress-wrapper\" role=\"progressbar\" aria-valuemin=\"0\" aria-valuemax=\"100\" aria-valuenow=\"65\" aria-valuetext=\"Research | Lead Optimization | Pre-Clinical Development | IND-Enabling | Phase 1\">\n\t\t\t<div class=\"elementor-progress-bar\" data-max=\"65\">\n\t\t\t\t<span class=\"elementor-progress-text\">Research | Lead Optimization | Pre-Clinical Development | IND-Enabling | Phase 1<\/span>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-13b8f3a elementor-widget elementor-widget-progress\" data-id=\"13b8f3a\" data-element_type=\"widget\" data-widget_type=\"progress.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t<span class=\"elementor-title\"><b style=\"font-size:20px\">SPX-102*<\/b> Target: CLDN 18.2-CDx<\/span>\n\t\t\n\t\t<div class=\"elementor-progress-wrapper\" role=\"progressbar\" aria-valuemin=\"0\" aria-valuemax=\"100\" aria-valuenow=\"65\" aria-valuetext=\"Research | Lead Optimization | Pre-Clinical Development | IND-Enabling | Phase 1\">\n\t\t\t<div class=\"elementor-progress-bar\" data-max=\"65\">\n\t\t\t\t<span class=\"elementor-progress-text\">Research | Lead Optimization | Pre-Clinical Development | IND-Enabling | Phase 1<\/span>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b148efe elementor-widget elementor-widget-progress\" data-id=\"b148efe\" data-element_type=\"widget\" data-widget_type=\"progress.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t<span class=\"elementor-title\"><b style=\"font-size:20px\">SPX-306<sup>+,1<\/sup><\/b> Target: Undisclosed<\/span>\n\t\t\n\t\t<div class=\"elementor-progress-wrapper\" role=\"progressbar\" aria-valuemin=\"0\" aria-valuemax=\"100\" aria-valuenow=\"49\" aria-valuetext=\"Research | Lead Optimization | Pre-Clinical Development | IND-Enabling\">\n\t\t\t<div class=\"elementor-progress-bar\" data-max=\"49\">\n\t\t\t\t<span class=\"elementor-progress-text\">Research | Lead Optimization | Pre-Clinical Development | IND-Enabling<\/span>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6e72246 elementor-widget elementor-widget-progress\" data-id=\"6e72246\" data-element_type=\"widget\" data-widget_type=\"progress.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t<span class=\"elementor-title\"><b style=\"font-size:20px\">SPX-603*<\/b> Target: VEGFxPD-L1-ADC<\/span>\n\t\t\n\t\t<div class=\"elementor-progress-wrapper\" role=\"progressbar\" aria-valuemin=\"0\" aria-valuemax=\"100\" aria-valuenow=\"40\" aria-valuetext=\"Research | Lead Optimization | Pre-Clinical Development\">\n\t\t\t<div class=\"elementor-progress-bar\" data-max=\"40\">\n\t\t\t\t<span class=\"elementor-progress-text\">Research | Lead Optimization | Pre-Clinical Development<\/span>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-29113ba elementor-hidden-desktop elementor-hidden-tablet elementor-hidden-mobile elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"29113ba\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-277bf41\" data-id=\"277bf41\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-5710b76 elementor-widget elementor-widget-progress\" data-id=\"5710b76\" data-element_type=\"widget\" data-widget_type=\"progress.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t<span class=\"elementor-title\">Candidate: SPX-101 | Target: CLDN 18.2<\/span>\n\t\t\n\t\t<div class=\"elementor-progress-wrapper\" role=\"progressbar\" aria-valuemin=\"0\" aria-valuemax=\"100\" aria-valuenow=\"90\" aria-valuetext=\"Discovery | Pharmacology | GLD\/GLP | IND Enabling |  IND | Phase 1\">\n\t\t\t<div class=\"elementor-progress-bar\" data-max=\"90\">\n\t\t\t\t<span class=\"elementor-progress-text\">Discovery | Pharmacology | GLD\/GLP | IND Enabling |  IND | Phase 1<\/span>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-31e22af elementor-widget elementor-widget-progress\" data-id=\"31e22af\" data-element_type=\"widget\" data-widget_type=\"progress.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t<span class=\"elementor-title\">Candidate: SPX-102 | Target: CLDN 18.2<\/span>\n\t\t\n\t\t<div class=\"elementor-progress-wrapper\" role=\"progressbar\" aria-valuemin=\"0\" aria-valuemax=\"100\" aria-valuenow=\"90\" aria-valuetext=\"Discovery | Pharmacology | GLD\/GLP | IND Enabling |  IND | Phase 1\">\n\t\t\t<div class=\"elementor-progress-bar\" data-max=\"90\">\n\t\t\t\t<span class=\"elementor-progress-text\">Discovery | Pharmacology | GLD\/GLP | IND Enabling |  IND | Phase 1<\/span>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-05f8ad2 elementor-widget elementor-widget-progress\" data-id=\"05f8ad2\" data-element_type=\"widget\" data-widget_type=\"progress.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t<span class=\"elementor-title\">Candidate: SPX-104 | Target: LILRB2<\/span>\n\t\t\n\t\t<div class=\"elementor-progress-wrapper\" role=\"progressbar\" aria-valuemin=\"0\" aria-valuemax=\"100\" aria-valuenow=\"50\" aria-valuetext=\"Discovery | Pharmacology | GLD\/GLP\">\n\t\t\t<div class=\"elementor-progress-bar\" data-max=\"50\">\n\t\t\t\t<span class=\"elementor-progress-text\">Discovery | Pharmacology | GLD\/GLP<\/span>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-88d5744 elementor-widget elementor-widget-progress\" data-id=\"88d5744\" data-element_type=\"widget\" data-widget_type=\"progress.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t<span class=\"elementor-title\">Candidate: SPX-301 | Target: CLDN X  Chkpt<\/span>\n\t\t\n\t\t<div class=\"elementor-progress-wrapper\" role=\"progressbar\" aria-valuemin=\"0\" aria-valuemax=\"100\" aria-valuenow=\"30\" aria-valuetext=\"Discovery | Pharmacology\">\n\t\t\t<div class=\"elementor-progress-bar\" data-max=\"30\">\n\t\t\t\t<span class=\"elementor-progress-text\">Discovery | Pharmacology<\/span>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-134defa elementor-widget elementor-widget-progress\" data-id=\"134defa\" data-element_type=\"widget\" data-widget_type=\"progress.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t<span class=\"elementor-title\">Candidate: SPX-302 | Target: Bispecific<\/span>\n\t\t\n\t\t<div class=\"elementor-progress-wrapper\" role=\"progressbar\" aria-valuemin=\"0\" aria-valuemax=\"100\" aria-valuenow=\"70\" aria-valuetext=\"Discovery | Pharmacology | GLD\/GLP | IND Enabling\">\n\t\t\t<div class=\"elementor-progress-bar\" data-max=\"70\">\n\t\t\t\t<span class=\"elementor-progress-text\">Discovery | Pharmacology | GLD\/GLP | IND Enabling<\/span>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ad894f3 elementor-widget elementor-widget-progress\" data-id=\"ad894f3\" data-element_type=\"widget\" data-widget_type=\"progress.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t<span class=\"elementor-title\">Candidate: SPX-303 | Target: LILRB2 X Chkpt<\/span>\n\t\t\n\t\t<div class=\"elementor-progress-wrapper\" role=\"progressbar\" aria-valuemin=\"0\" aria-valuemax=\"100\" aria-valuenow=\"42\" aria-valuetext=\"Discovery | Pharmacology | GLD\/GLP\">\n\t\t\t<div class=\"elementor-progress-bar\" data-max=\"42\">\n\t\t\t\t<span class=\"elementor-progress-text\">Discovery | Pharmacology | GLD\/GLP<\/span>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-27e4f49 elementor-widget elementor-widget-progress\" data-id=\"27e4f49\" data-element_type=\"widget\" data-widget_type=\"progress.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t<span class=\"elementor-title\">Candidate: SPX-304 | Target: Bispecific<\/span>\n\t\t\n\t\t<div class=\"elementor-progress-wrapper\" role=\"progressbar\" aria-valuemin=\"0\" aria-valuemax=\"100\" aria-valuenow=\"30\" aria-valuetext=\"Discovery | Pharmacology\">\n\t\t\t<div class=\"elementor-progress-bar\" data-max=\"30\">\n\t\t\t\t<span class=\"elementor-progress-text\">Discovery | Pharmacology<\/span>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1e37ea9 elementor-widget elementor-widget-progress\" data-id=\"1e37ea9\" data-element_type=\"widget\" data-widget_type=\"progress.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t<span class=\"elementor-title\">Candidate: SPX-306 | Target: Bispecific<\/span>\n\t\t\n\t\t<div class=\"elementor-progress-wrapper\" role=\"progressbar\" aria-valuemin=\"0\" aria-valuemax=\"100\" aria-valuenow=\"35\" aria-valuetext=\"Discovery | Pharmacology\">\n\t\t\t<div class=\"elementor-progress-bar\" data-max=\"35\">\n\t\t\t\t<span class=\"elementor-progress-text\">Discovery | Pharmacology<\/span>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-706709f elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"706709f\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-8a30cbf\" data-id=\"8a30cbf\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-1c2aadc elementor-icon-list--layout-traditional elementor-list-item-link-full_width elementor-widget elementor-widget-icon-list\" data-id=\"1c2aadc\" data-element_type=\"widget\" data-widget_type=\"icon-list.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<ul class=\"elementor-icon-list-items\">\n\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-circle\"><\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">Internal Pipeline<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t<\/ul>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e847496 elementor-icon-list--layout-traditional elementor-list-item-link-full_width elementor-widget elementor-widget-icon-list\" data-id=\"e847496\" data-element_type=\"widget\" data-widget_type=\"icon-list.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<ul class=\"elementor-icon-list-items\">\n\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-circle\"><\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">Collaboration Pipeline<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t<\/ul>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f002917 elementor-widget elementor-widget-image\" data-id=\"f002917\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"150\" height=\"150\" src=\"\/app\/uploads\/2025\/04\/image10-2-2.svg\" class=\"attachment-thumbnail size-thumbnail wp-image-3866\" alt=\"\" loading=\"lazy\" \/>\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\">Global Right<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d7df1a1 elementor-widget elementor-widget-image\" data-id=\"d7df1a1\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"150\" height=\"150\" src=\"\/app\/uploads\/2025\/04\/cn-150x150.webp\" class=\"attachment-thumbnail size-thumbnail wp-image-3855\" alt=\"\" loading=\"lazy\" \/>\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\">China Right<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>The SparX Selected IO &#038; Nab2-ADC Pipeline Candidate Target Research Lead Optimization Pre-Clinical Development IND-Enabling Phase I Phase II SPX-303 LILRB2xPDL1 Mayo Clinic (Minnesota, Arizona &#038; Florida) HonorHealth First-in-Class LILRB2xPDL1+T-DXd MRCT &#038; in combination with T-DXd First-in-Class SPX-629 HER2 Dual-Payload ADC (TOP1i \u00d7 MMAE) Best-in-Class SPX-602 VEGFxPDL1-ADC (TOP1i \u00d7 MMAE) First-in-Class SPX-608 Immune-Targeting Dual Payload [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"\/index.php?rest_route=\/wp\/v2\/pages\/3238"}],"collection":[{"href":"\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=3238"}],"version-history":[{"count":80,"href":"\/index.php?rest_route=\/wp\/v2\/pages\/3238\/revisions"}],"predecessor-version":[{"id":3899,"href":"\/index.php?rest_route=\/wp\/v2\/pages\/3238\/revisions\/3899"}],"wp:attachment":[{"href":"\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=3238"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}